For keeping track of my students' grades and more, I have long used EasyGrade Pro. A paid upgrade to v4 appeared for the desktop and Windows Mobile versions earlier this year, but the Palm version had to wait a bit longer due to Vista troubles. Those have apparently been solved, because EGP Clipboard 4 is now available.
I've already convinced another colleague in Japan to go with EasyGrade Pro and I'll soon send out my upgrade orders for this wonderful program and its Palm companion.